Endocrine Abstracts

Clinically non-functioning pituitary adenomas account for about one-third of pituitary tumors. The majority of them are pathologically classified as gonadotropinomas or null-cell adenomas without hormonal expression. The rest represent silent corticotroph adenomas and plurihormonal tumors. Conservative therapy with dopamine agonists and somatostatine analogues is effective in some cases only depending on the expression of somatostatine (SSTR) and dopamine 2 receptors (D2R).</p...

Introduction: Hypothalamo-pituitary dysfunction has been reported in patients after traumatic brain injury or subarachnoid hemorrhage with relatively high frequency according to published studies. Assessment of hypothalamo– pituitary functions in patients with chronic subdural hematomas has not been published yet, although dysfunction of hypothalamo- pituitary unit could be expected (head trauma, compression and oedema of the brain, shifting of the midline structures).</p...

Introduction: Excess glucocorticoid (GC) activity has been implicated in the pathophysiology of multiple cancer types. For instance, approximately half of adrenocortical carcinoma (ACC) patients exhibit excess GC (GC+). This provides a unique opportunity to study correlates of GC activity, such as a possible suppression of tumor immune response and immune checkpoint inhibitor (ICI) efficacy due to the broad immunosuppressive effects of GC. ACC multi-omics data can be used ...

Acromegaly is frequently diagnosed late and pituitary macroadenoma is revealed in the majority of patients. Treatment usually needs combination of several treatment modalities to suppress the disease activity. Efficacy of our treatment of acromegaly was not analysed till now.Aim: First analysis of the diagnostics of acromegaly, efficacy of treatment, its complications and status of acromegaly patients in six tertiary referral centers in the Czech Republi...